Embryo-maternal Immunomodulation during early pregnancy
Ulbrich, Heinrich H.D. Meyer, Ralf Einspanier
How do maternal cells recognize an
embryo without rejection due to histoincompatibility?
During early pregnancy physiological mechanisms protect
the bovine embryo against an immunoreaction of the
surrounding maternal cells. The hypothesis is that a
number of functional complexes are involved in modulating
the immunocompetence of the endometrium in supporting
Based on previous findings the mRNA and
protein expression of candidate genes of different
functional complexes in the endometrium and in cells of
the intrauterine fluid will be systematically analyzed in
pregnant and non-pregnant animals of the pre-attachment
period. The function of selected local factors will be
confirmed using RNAi in vitro. Changes in abundance of
genes involved in immunomodulatory pathways will give
insights into the support of the endometrium towards the
conceptus and will especially enlighten immunomechanisms
during early pregnancy.
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